The Entourage Effect: Maximizing the Benefits of Medicinal Cannabis Therapy

The Entourage Effect: Maximizing the Benefits of Medicinal Cannabis Therapy

What is the Entourage Effect

Medical cannabis therapy has gained popularity in recent years as an alternative or complementary treatment option for various conditions. While the active compounds in cannabis, namely cannabinoids, are widely recognized for their therapeutic properties, the full potential of medical cannabis lies in the synergistic relationship between different components in the plant. This synergy is known as the entourage effect.

The Entourage Effect

The entourage effect refers to the combined impact of the three significant therapeutic classes of compounds in medical cannabis: cannabinoids, terpenoids, and flavonoids. These compounds work together to create a potent and more effective therapeutic effect.


Cannabinoids are the main active compounds in medical cannabis, with tetrahydrocannabinol (THC) and cannabidiol (CBD) being the most well-known. They interact with the body's endocannabinoid system, which is involved in regulating various functions such as mood, appetite, and sleep.


Terpenoids are fragrant oils found in plants that provide their unique aromas. In medical cannabis, they interact with the endocannabinoid system and enhance the therapeutic benefits of cannabinoids.


Flavonoids are a diverse group of compounds that provide the color and flavor of many plants, including cannabis. They have been shown to have potent anti-inflammatory, antioxidant, and neuroprotective effects, among others.

Whole Plant Extractions

For medical use, whole plant extractions that contain a mix of cannabinoids, terpenoids, and flavonoids are highly recommended. Ethanol is a commonly used solvent that can extract all three medicinal fractions efficiently, but it can also strip away undesirable compounds like chlorophyll, concrete oils, and waxes. To minimize these, a quick cold wash process that involves freezer cooling the ethanol and raw cannabis material can be used.

Proper Dosing

Proper dosing is crucial in maximizing the benefits of medicinal cannabis therapy. Factors such as individual tolerance, the condition being treated, and the specific strain used can all affect the ideal dose. It is essential to start with a low dose and gradually increase as needed, under the supervision of a healthcare professional.


The entourage effect is a crucial aspect of medical cannabis therapy that can enhance its therapeutic benefits. By understanding the synergistic relationship between cannabinoids, terpenoids, and flavonoids, patients can maximize the therapeutic effects of their treatment. However, proper dosing is essential to avoid adverse effects and ensure the best outcomes.

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